Cyclic hiv principal neutralizing determinant peptides

Details Cyclic hiv principal neutralizing determinant peptides Cyclic hiv principal neutralizing determinant peptides

C - Chemistry, Metallurgy

07

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C07K 14/155 (2006.01) A61K 47/48 (2006.01) C07K 7/54 (2006.01) C07K 7/56 (2006.01) C07K 7/64 (2006.01) C07K 14/16 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2058876

157/GHB50 18149IB TITLE OF THE INVENTION CYCLIC HIV PRINCIPAL NEUTRALIZING DETERMINANT PEPTIDES ABSTRACT OF THE DISCLOSURE Cyclic Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinant (PND) peptides, or peptides immunologically equivalent therewith, wherein the ring system of the cyclic peptide is formed by ring closure through a stable amide bond, are useful as analytical tools, as reagents in ELISA assays, or as reagents for making covalent conjugate immunogens. Conjugates containing these stable, cyclic peptides are useful for raising mammalian anti-peptide, anti-HIV, or HIV-neutralizing immune responses, and a composition containing such a conjugate may be used as a vaccine to prevent HIV-Disease, including Acquired Immune Deficiency Syndrome, (AIDS), or AIDS related complex, (ARC), or as an immunogen for treating humans afflicted with HIV-Diseases, such as AIDS or ARC.

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