C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 259/08 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) C07D 211/16 (2006.01) C07D 211/22 (2006.01) C07D 211/60 (2006.01) C07D 213/30 (2006.01) C07D 213/40 (2006.01) C07D 215/20 (2006.01) C07D 215/22 (2006.01) C07D 215/233 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2333554
The present application describes novel cyclic hydroxamic acids of formula (I): or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5- 7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa and S(O)p, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease inhibitors.
La présente invention se rapporte à de nouveaux acides hydroxamiques cycliques représentés par la formule (I) ou à des sels pharmaceutiquement acceptables de ces acides. Dans la formule (I), le noyau B est un système cyclique comportant 5 à 7 éléments possédant 0 à 2 hétéroatomes sélectionnés parmi O, N, NR?a¿, et S(O)¿p?, et 0 à 1 groupe carbonyle, et les autres variables sont définies dans la description associée à la présente invention. Ces acides s'avèrent utiles en tant qu'inhibiteurs de métalloprotéases.
Decicco Carl P.
He Xiaohua
Xue Chu-Baio
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
Dupont Pharmaceuticals Company
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