C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/496 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) A61P 13/12 (2006.01) A61P 27/06 (2006.01) C07D 401/04 (2006.01) C07D 403/06 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2712854
The present invention relates to cyclic indole-3-carboxamides of the Formula (I), wherein A, R, R10, R20, R30, R40, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the Formula (I), their use and pharmaceutical compositions comprising them.
L'invention concerne des indole-3-carboxamides cycliques représentés par la formule (I), dans laquelle A, R, R10, R20, R30, R40, n, p et q ont les significations indiquées dans les revendications, qui sont des composés pharmaceutiques actifs intéressants. Ces composés permettent, de manière plus spécifique d'inhiber la rénine enzymatique et de moduler l'activité du système rénine-angiotensine, et sont utilisés pour traiter des maladies, telles que par exemple l'hypertension. L'invention concerne également des procédés de préparation des composés représentés par la formule I, leur utilisation et des compositions pharmaceutiques comprenant lesdits composés.
Matter Hans
Mccort Gary
Scheiper Bodo
Steinhagen Henning
Stilz Hans Ulrich
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis
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