C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/10 (2006.01) A61K 31/5355 (2006.01) A61P 5/44 (2006.01)
Patent
CA 2759047
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 ß-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Cette invention porte sur de nouveaux composés de Formule Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, sur des sels pharmaceutiquement acceptables de ceux-ci et sur des compositions pharmaceutiques de ceux-ci, qui sont utiles pour le traitement thérapeutique de maladies associées à la modulation ou à l'inhibition de 11béta-HSD1 chez les mammifères. Cette invention porte en outre sur des compositions pharmaceutiques des nouveaux composés et sur des procédés pour leur utilisation dans la réduction ou dans la régulation de la production de cortisol dans une cellule ou l'inhibition de la conversion de cortisone en cortisol dans une cellule.
Renz Martin
Schuele Martin
Xu Zhenrong
Boehringer Ingelheim International Gmbh
Gowling Lafleur Henderson Llp
Vitae Pharmaceuticals Inc.
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