Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1

Details Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) A61K 31/5355 (2006.01) A61P 19/10 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2722427

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 .beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.

La présente invention concerne de nouveaux composés de formule Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, leurs sels pharmaceutiquement acceptables, et leurs compositions pharmaceutiques, qui sont utiles pour le traitement thérapeutique de pathologies associées à la modulation ou à linhibition de la 11-ß-HSD1 chez les mammifères. Linvention concerne en outre des compositions pharmaceutiques des nouveaux composés et leurs méthodes dutilisation dans la réduction ou la régulation de la production de cortisol dans une cellule ou linhibition de la conversion de la cortisone en cortisol dans une cellule.

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