Cyclic ketal derivatives

Details Cyclic ketal derivatives Cyclic ketal derivatives

C - Chemistry, Metallurgy

12

P

C12P 17/18 (2006.01) A61K 31/34 (2006.01) C07D 493/08 (2006.01) C07H 9/04 (2006.01) C07H 19/01 (2006.01) C12P 19/02 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2106072

2106072 9216530 PCTABS00016 Compounds are described of formula (I) wherein R1 represents a hydrogen atom or an acetyl group; R2, R3 and R4 may each independently represent a hydrogen atom or a methyl group; n represents an integer from 1 to 3; and the fluorine atom(s) present may be attached at the ortho, meta or para position of the benzene ring relative to the rest of the molecule; and salts thereof. These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the invention may be formulated for use in a variety of conditions where a lowering of the level of blood plasma cholesterol in animals would be beneficial and for use in combating fungal infections in animals.

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