C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/207, 167/274
C07C 251/58 (2006.01) A61K 31/15 (2006.01) A61K 31/33 (2006.01) C07D 213/16 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01) C07D 317/58 (2006.01)
Patent
CA 2023957
NOVEL AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME A B S T R A C T The invention relates to novel racemic or optically active aminopropanol derivatives of formula I Image I wherein R and R1 are independently hydrogen atom, halogen atom, lower alkoxy, or together represent a methylene dioxy group, R2 and R3 together represent a chemical bond or independently stand for a hydrogen atom, R4 and R5 are independently hydrogen atom, C3-7 cycloalkyl group or straight or branched, saturated or unsaturated C1-12 alkyl group optionally substituted by one or more dialkyl- -aminoalkyl, dimethoxyphenyl or phenyl groups, or R4 and R5 together with the adjacent nitrogen atom form a 4 to 7 membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which ring is optionally substituted by a phenyl, benzyl or C1-3 alkyl group and the said substituents may carry a hydroxyl group, one or two methoxy groups, halogen atoms or trifluoro- methyl groups, or R4 and R5 together with the adjacent nitrogen atom form a piperidine ring which is optionally substituted by a phenyl or benzyl group and, if desired, it comprises a double bond, R6 stands for hydrogen atom or benzoyl group, and n represents an integer from 3 to 6, acid-addition salts and quaternary ammonium derivatives thereof. Further the invention relates to processes for preparing these compounds. The compounds of the invention exert cardiac circulation controlling and/or improving, central nervous system tranquillizing and/or digestive system irregulations improving effects.
Budai Zoltan
Fekete Marton
Gigler Gabor
Hoffmann Nee Fekete Valeria
Kapolnai Laszlo
Egis Gyogyszergyar Rt.
Fetherstonhaugh & Co.
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