C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/18 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61K 38/00 (2006.01) A61P 25/28 (2006.01) C07D 243/14 (2006.01) C07D 243/24 (2006.01) C07D 407/12 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01)
Patent
CA 2403550
This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.
L'invention concerne des lactames représentés par la formule (I), leurs compositions pharmaceutiques et leurs procédés d'utilisation. Ces composants inhibent le traitement de la protéine précurseur amyloïde, et plus spécifiquement, la production de peptide A.beta.. Cela permet d'empêcher la formation de dépôts neurologiques de protéine amyloïde. L'invention concerne plus particulièrement le traitement de troubles neurologiques en relation avec la production d'amyloïde .beta., et notamment de la maladie d'Alzheimer et du syndrome de Down. Formule (I)
Liu Hong
Yang Michael G.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
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