Cyclic lactams as inhibitors of a.beta. protein production

Details Cyclic lactams as inhibitors of a.beta. protein production Cyclic lactams as inhibitors of a.beta. protein production

C - Chemistry, Metallurgy

07

D

C07D 223/18 (2006.01) A61K 31/4015 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61K 31/5513 (2006.01) A61K 38/00 (2006.01) A61P 25/28 (2006.01) C07D 223/12 (2006.01) C07D 223/16 (2006.01) C07D 243/14 (2006.01) C07D 243/24 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) C07K 5/08 (2006.01) C07K 5/087 (2006.01)

Patent

CA 2404023

This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.

Cette invention concerne de nouveaux malonamides cycliques de la formule (I), leurs compositions pharmaceutiques et leurs méthodes d'utilisation. Ces nouveaux composés inhibent le traitement de la protéine précurseur amyloïde et, notamment, la production du peptide .beta.-amyloïde, en agissant pour prévenir la formation de dépôts neurologiques de la protéine amyloïde. L'invention concerne plus particulièrement le traitement de troubles neurologiques associés à la production de .beta.-amyloïdes, tels que la maladie d'Alzheimer ou le syndrome de Down.

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