Cyclic monophosphates of purine and pyrimidine...

Details Cyclic monophosphates of purine and pyrimidine... Cyclic monophosphates of purine and pyrimidine...

C - Chemistry, Metallurgy

07

F

167/218, 260/251

C07F 9/6574 (2006.01) A61K 31/665 (2006.01)

Patent

CA 2009110

089/TTR1 17872 TITLE OF THE INVENTION CYCLIC MONOPHOSPHATES OF PURINE AND PYRIMIDINE ACYCLONUCLEOSIDES ABSTRACT OF THE INVENTION A compound having the formula B-CH2-X-Z wherein B is a pyrimidine, a substituted pyrimidine, a purine, a substitued purine wherein the substituents on the purine or pyrimidine are selected from amino, hydroxyl, halogen, thio or alkylthiol wherein the alkyl moiety of the alkylthiol has 1 to 6 carbons and the purine or substituted purine is not guanine; X is oxygen, sulfur or methylene; Z is Image or Image and R is hydrogen or a pharmaceutically acceptable cation. 089/TTR1 - i - 17872 These compounds have antiviral activity and are effective against the herpes class of viruses such as herpes simplex and cytomegalovirus.

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