Cyclic natriuretic peptide constructs

Details Cyclic natriuretic peptide constructs Cyclic natriuretic peptide constructs

A - Human Necessities

61

K

A61K 38/12 (2006.01)

Patent

CA 2647143

Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R', Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti hypertensive, cardiovascular, renal or endocrine effects are desired.

La présente invention concerne des constructions cycliques avec un N-terminal et un C-terminal de liaison à un récepteur aux peptides natriurétiques et comportant une pluralité de résidus d'acides aminés, au moins un succédané d'acide aminé de formule (I), dans laquelle: R, R', Q, Y, W, Z, J, x et n sont tels que définis dans la description, et éventuellement au moins un groupe de substitution, des compositions pharmaceutiques comportant de telles constructions cycliques, et des procédés de traitement de l'insuffisance cardiaque congestive ou d'autres conditions pathologiques, syndromes ou maladies pour lesquels une induction d'effets anti-hypertensifs, cardio-vasculaires, rénaux ou endocriniens sont souhaités.

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