Cyclic neurokinin a antagonists

Details Cyclic neurokinin a antagonists Cyclic neurokinin a antagonists

C - Chemistry, Metallurgy

07

K

530/7.06, 530/7.

C07K 7/56 (2006.01) A61K 38/12 (2006.01) C07K 7/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2022740

Antagonists of neurokinin A which are derivatives of naturally occurring neurokinin A in which the amide bond connecting the two amino acids on the carboxy terminal end is modified are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which neurokinin A is implicated is also described.

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