Cyclic neurokinin a antagonists

Details Cyclic neurokinin a antagonists Cyclic neurokinin a antagonists

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) A61K 38/12 (2006.01) C07K 7/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2182486

Antagonists of neurokinin A which are novel cyclic hexapeptide and octapeptide compounds are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which neurokinin A is implicated is also described.

L'invention concerne des antagonistes de la neurokinine A qui sont de nouveaux composés cycliques hexapeptidiques et octapeptidiques. L'antagonisme est confirmé au moyen de dosages biochimiques et de dosages à liaison compétitive classiques ainsi que de tests physiologiques. L'invention concerne également l'utilisation de ces dérivés dans le traitement de plusieurs troubles dans lesquels la neurokinine A joue un rôle.

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