Cyclic nitrones

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 217/08 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) C07D 209/44 (2006.01) C07D 209/96 (2006.01) C07D 217/24 (2006.01) C07D 221/20 (2006.01) C07D 223/16 (2006.01) C07D 223/32 (2006.01)

Patent

CA 2077708

The present invention is directed to a new class of cyclic nitrones of the formula: (see formula I) in which R1 and R2 are each independently represented by a C1-3 alkyl or R1 and R2 together form a C2-7 alkyl chain, n is represented by an integer from 0 to 2, and R3 is repre- sented by a substituent selected from the group consisting of hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, -CF3, -OCF3 and -OH. These nitrones are useful as spin trapping agents.

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