C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.64, 167/10
C07K 7/64 (2006.01) C07K 14/655 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1261548
Cyclic octapeptides and pharmaceutical preparations thereof, as well as processes for their manufacture, and their use. Abstract Cyclic octapeptides of the formula Image (I) in which Aaa represents a radical of a straight-chained .alpha.,.omega.-diaminoalkanoic acid having from 4 to 7 carbon atoms, trp represents a radical L-Trp or, especially, D-Trp, or a radical derived therefrom, which carries a halogen atom in the indole nucleus AcA represents an acyl radical Ac of an option- ally substituted carboxylic acid which is positioned at the .omega.-amino group, or represents an amidino group or hydrogen, and AcB represents an acyl radical Ac1 of an amino acid or of an oligopeptide which is positioned at the .epsilon.-amino group, or, preferably, repre- sents hydrogen, as well as physiologically tolerable salts and thera- peutically acceptable complexes thereof can be used as antidiabetics and for the treatment of gastro- intestinal bleeding in an analogous manner to somatostatin. They can be obtained by conventional processes of peptide chemistry, especially by the cyclisation of corresponding linear peptides.
418437
Fetherstonhaugh & Co.
Novartis Ag
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