Cyclic peptide compounds and their production process

Details Cyclic peptide compounds and their production process Cyclic peptide compounds and their production process

C - Chemistry, Metallurgy

07

K

C07K 5/12 (2006.01) A61K 38/12 (2006.01) C12P 21/02 (2006.01) C12P 21/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223360

This invention provides processes for producing novel cyclic peptide compounds, which comprise, cultivating Ctenomyces serratus FERM BP-5731 and thenisolating the cyclic peptide compounds from the fermentation broth. The compounds produced by these processes include a cyclic peptide compound of the following formula (I) Image (I) The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of severe pain, detoxication of narcotics dependency or acute narcotics intoxication or the like.

L'invention porte sur des méthodes pour préparer de nouveaux peptides cycliques, consistant à cultiver Ctenomyces serratus FERM BP-5731, puis à isoler les peptides cycliques à partir du bouillon de fermentation. Parmi les composés ainsi produits figure un peptide cyclique de formule (I) Image . L'invention porte également sur une composition pharmaceutique à base de ce type de peptide, utile pour le traitement de fortes douleurs ou pour soigner les toxicomanes ou les personnes souffrant d'intoxication aiguë par des narcotiques.

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