Cyclic peptides

Details Cyclic peptides Cyclic peptides

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) C07K 5/04 (2006.01) C07K 7/06 (2006.01) C07K 17/14 (2006.01)

Patent

CA 2046124

ABSTRACT OF THE DISCLOSURE A novel peptide represented by formula (I): Cyclo-(Cys-Val-d-Phe-Pro)2 (I) wherein Cys indicates a cysteine group, Val indicates a valine group, d-Phe indicates a d-phenylalanine group, Pro indicates a proline group, and Cyclo indicates a cyclic form. This peptide is formed by way of active esterification or azidation of an intermediate: Boc-Cys(Acm)-Val-Cys(Acm)-d-Phe-Pro-OME wherein Boc indicates an amino group protected by a t- butyloxycarbonyl group, Acm indicates an SH group protected by an acetamidomethyl group, and OMe indicates a methoxylated carboxyl group.

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