C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/64 (2006.01) A61K 38/12 (2006.01) A61K 39/385 (2006.01) A61K 38/11 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2389196
Cyclic peptides containing as the constituent chain one or two amino acid sequences selected from between Asn-Val-Ser-Glu-Ala-Asp-Asp-Arg-Tyr-Ile and Arg-Ser-Gln-Lys-Glu-Gly-Leu-His-Tyr-Thr; and AIDS vaccines containing these peptides as the active ingredient. It is preferable from the standpoints of bioabsorbability and development of an antibody that the active groups of the peptides selected from among carboxyl, amino and hydroxyl be bonded to substituents. The cyclic peptides can neutralize the second receptor which HIV- 1 viruses utilize in invading into the human body.
La présente invention concerne des peptides cycliques contenant comme chaînes de constitution une ou deux séquences d'acides aminés choisies parmi Asn-Val-Ser-Glu-Ala-Asp-Asp-Arg-Tyr-Ile et Arg-Ser-Gln-Lys-Glu-Gly-Leu-His-Tyr-Thr. L'invention concerne également des vaccins contre le SIDA contenant ces peptides cycliques comme principes actifs. Considérant la bio-absorbabilité et le développement d'un anticorps, il est préférable que les groupes actifs des peptides choisis parmi des groupes carboxyles, amino et hydroxyles soient liés à des substituants. Les peptides cycliques de l'invention permettent de neutraliser le second récepteur intervenant dans l'infection par le HIV-1 chez l'homme.
Fetherstonhaugh & Co.
Nissui Pharmaceutical Co. Ltd.
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