Cyclic peptides and medicinal use thereof

Details Cyclic peptides and medicinal use thereof Cyclic peptides and medicinal use thereof

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) A61K 38/12 (2006.01)

Patent

CA 2278030

Cyclic peptides represented by general formula (I) and having VLA-4 adhesion inhibitory activities, and the use thereof as remedies for allergic inflammations or hepatitis. In said formula, A and F represent each Cys, Asp, etc.; B represents Ala etc.; C represents Asp analog etc.; D represents Tyr etc.; E represents Leu etc.; G represents a disulfide or amide linkage; R1 represents hydrogen or acyl; and R2 represents hydrogen or alkyl.

L'invention porte sur des peptides cycliques représentés par la formule générale (I) et présentant des activités inhibitrices d'adhésion de VLA-4. Ces peptides sont utilisés comme remèdes des inflammations allergiques ou de l'hépatite. Dans cette formule, A et F représentent chacun Cys, Asp, etc.; B représente Ala, etc.; C représente Asp, un analogue, etc.; D représente Tyr, etc.; E représente Leu, etc.; G représente une liaison bisulfure ou amide; R¿1? représente hydrogène ou acyle; et R¿2? représente hydrogène ou alkyle.

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