C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/04 (2006.01) C07K 7/06 (2006.01) C07K 7/54 (2006.01) C07K 7/64 (2006.01) C07K 14/75 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2073696
2073696 9111458 PCTABS00006 A small cyclic peptide is provided having high affinity for the platelet GP IIbIIIa receptor, which peptide is represented by formula .alpha. where R1 and R4 are from 0 to 4 amino acids, R3 is from 1 to 4 amino acids; R2 is -CH2CO- or from 1 to 4 amino acids; Xaa8 may be Met, Phe, nLeu, Ile, Asp, Lys, Arg and Gln; and Z is a linking group, either disulfide, thioether or amide, but preferably disulfide. Preferred cyclic peptides exhibiting high inhibition potency in a platelet aggregation assay are represented by formula .beta. where Xaa2, Xaa3 and Xaa4 may be any amino acid but preferably are Arg, Ile and Pro, respectively. Xaa8 is preferably Met, Phe or nLeu; Xaa10 when present, is preferably Ala; and Xaa11, when present, is preferably Ala or Asp. These compounds may be effectively employed in a pharmaceutical composition containing a pharmaceutically acceptable excipient for reducing platelet aggregation in a mammal. The pharmaceutical composition is especially useful in treating a mammal having an increased propensity for thrombus formation, and may be used in combination with an anticoagulant or thrombolytic agent.
Barker Peter L.
Burnier John P.
Lazarus Robert A.
Barker Peter L.
Burnier John P.
Genetech Inc.
Johnson Douglas S. Q.c.
Lazarus Robert A.
LandOfFree
Cyclic peptides containing arg-gly-asp flanked by proline does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclic peptides containing arg-gly-asp flanked by proline, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic peptides containing arg-gly-asp flanked by proline will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2062762