Cyclic peptides that bind to urokinase-type plasminogen...

Details Cyclic peptides that bind to urokinase-type plasminogen... Cyclic peptides that bind to urokinase-type plasminogen...

C - Chemistry, Metallurgy

07

K

C07K 7/54 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2277832

Cyclic peptide compounds having 11 amino acids joined by a linking unit (L), such that the linear dimension between the C.alpha. carbon of the first amino acid and the C.alpha. carbon of eleventh amino acid is between about 4 and 12 .ANG.ngstrom units; are useful for inhibiting the binding of µPA to the µPAR receptor. Methods for using the cyclic peptide compounds, and compositions containing them, for inhibiting the growth or metastasis of cancerous tumors are also disclosed.

L'invention porte sur des composés peptidiques cycliques possédant 11 acides aminés réunis par une unité de liaison (L) de sorte que la dimension linéaire entre le carbone C< alpha > du premier acide aminé et le carbone C< alpha > du onzième acide aminé est compris entre environ 4 et 12 unités ANGSTROM ngstrom. Ces composés sont utiles pour inhiber la liaison d'uPA au récepteur d'uPAR. L'invention porte contenant également sur des procédés d'utilisation de ces composés peptides cycliques et leurs compositions qui inhibent la prolifération ou la métastase des tumeurs cancéreuses.

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