Cyclic peptolides

Details Cyclic peptolides Cyclic peptolides

C - Chemistry, Metallurgy

12

P

195/89, 195/128.

C12P 21/04 (2006.01) A61K 38/12 (2006.01) C07K 7/64 (2006.01) C07K 11/02 (2006.01) C12N 1/14 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1338183

Cyclic peptolides having the structure of a cyclosporin in which one amide linkage is replaced by an ester linkage are obtained by fermentation of fungal strains of the genus Cylindrotrichum Bonorden, or by cyclisation of a hydroxy-undecapeptide. The cyclic peptolides have immunosuppressive, anti-inflammatory and anti-parasitic properties.

569655

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