Cyclic phosphonate ester inhibitors of microsomal...

Details Cyclic phosphonate ester inhibitors of microsomal... Cyclic phosphonate ester inhibitors of microsomal...

A - Human Necessities

61

K

A61K 31/675 (2006.01) A61K 31/66 (2006.01) C07F 9/58 (2006.01) C07F 9/59 (2006.01) C07F 9/653 (2006.01) C07F 9/6533 (2006.01) C07F 9/6541 (2006.01) C07F 9/6571 (2006.01) C07F 9/6574 (2006.01)

Patent

CA 2307889

Novel cyclic phosphonate ester inhibitors of MTP are provided which have structure (I) wherein R2, L2, A, B, L1, R1 and R5a are as set out herein. These compounds are useful in lowering serum cholesterol and triglycerides.

Nouveaux inhibiteurs phosphonate ester cyclique de MTP de structure (I) dans laquelle R?2¿, L?2¿, A, B, L?1¿, R?1¿ et R?5a¿ sont tels que décrits dans le descriptif. Ces composés sont utiles pour abaisser le taux sérique de cholestérol et de triglycérides.

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