C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/330, 260/293
C07D 331/02 (2006.01) C07D 295/096 (2006.01) C07D 295/12 (2006.01) C07D 303/14 (2006.01) C07D 303/16 (2006.01) C07D 303/22 (2006.01) C07D 303/26 (2006.01) C07D 303/36 (2006.01)
Patent
CA 1063120
Abstract This invention relates to new cyclic polymethylene phenoxy-aminopropanols and related compounds, which are useful in coronary diseases, lowering blood pressure, as central nervous system depressants, water softening and corrosion inhibition, having the formula Image wherein the aminopropoxy chain is in the 1- or 2- position, wherein R3, R4, R5, R6 and R7 are the same or different and are hydrogen or lower alkyl, R8, R9 and R10 are the same or different and are hydrogen, lower alkyl, aralkyl, lower alkoxy, carboxy, monocyclic cycloalkyl, lower alkenyl, nitro, halogen, acyl, amino, acylamino, R14O(CH2)n'- where R14 is hydrogen, lower alkyl or aralkyl and n' is 0,1 or 2; the radical Image is a basic nitrogen containing radical of up to about 18 carbons, Z and Z1 are the same or different and are hydrogen, formyl, cyano, azido, R15-X or R16-Y-, wherein X and Y are ?, -(CH2)n2 where n2 is 1 to 8, -0-, -S-, Image where R17 is hydrogen or acyl and R15 and R15 are the same or different and are hydrogen, lower alkyl, lower alkoxy, hydroxy aryl, acyl, lower alkenyl or Image , R11 is hydrogen, lower alkyl or aralkyl, n is 0, 1 or 2; the dashed lines indicate that Z2 is or is not present, where Z2 is present, Z2 is Image wherein R12 and R13 are the same or different and are hydrogen, lower alkyl, aryl, hydroxy, alkoxy, aryloxy or amino, with the proviso that where n is 1 and Z and Z1 are in the 6- and 7- positions, either or both of Z and Z1 are other than hydrogen or acyl, and pharmaceutically acceptable acid addition salts thereof.
175417
Cimarusti Christopher M.
Hauck Frederic P.
Sundeen Joseph E.
E.r. Squibb And Sons
Na
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