Cyclic prosaposin-derived peptides and uses thereof

Details Cyclic prosaposin-derived peptides and uses thereof Cyclic prosaposin-derived peptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61P 25/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2341810

Cyclic neurotrophic and analgesic peptides derived from the active region of prosaposin having the consensus sequence X1X2X3NNX4TX5X6X7X8 (SEQ ID NO:4), wherein X1 is a hydrophobic amino acid (leucine, isoleucine, valine, tyrosine, tryptophan, phenylalanine or methionine); X2 is a hydrophobic amino acid, X3 is aspartic acid, glutamic acid, lysine or arginine; N is asparagine, X4 is any amino acid; T is threonine; X5 is glutamic acid or aspartic acid; X6 is any amino acid, X7 is a hydrophobic amino acid; and X8 is a hydrophobic amino acid. The peptides are useful in the promotion of neural outgrowth, prevention of cell death, promotion of myelination, treatment of neurodegenerative disorders and treatment and prevention of neuropathic pain.

L'invention concerne des peptides cycliques neurotrophiques et analgésiques issus de la région active de la prosaposine et présentant une séquence consensus X¿1?X¿2?X¿3?NNX¿4?TX¿5?X¿6?X¿7?X¿8? (SEQ. ID NO. 4) dans laquelle X¿1? est un acide aminé hydrophobe (leucine, isoleucine, valine, tyrosine, tryptophan, phénylalanine ou méthionine); X¿2? est un acide aminé hydrophobe; X¿3? est un acide aspartique, un acide glutamique, lysine or arginine; N est asparagine, X¿4? est un quelconque acide aminé; T est thréonine, X¿5? est un acide glutamique ou un acide aspartique; X¿6? est un quelconque acide aminé, X¿7? est un acide aminé hydrophobe; et X¿8? est un acide aminé hydrophobe. Ces peptides sont utiles pour l'activation de l'excroissance neuronale, la prévention de la mort cellulaire, l'activation de la myélinisation, le traitement de troubles neurodégénératifs et le traitement et la prévention de douleurs neurophatiques.

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