C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01) A61K 31/452 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2526880
Compounds of formula (1) wherein,m,n,R1,R2,Ra,ALK3, E and Y are as defined in the claims, being potent and selective inhibitors of chemokine binding to the CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammatory, autoimmune and immurforegulatory disorders such as rheumatoid arthritis.
L'invention concerne des composés de formule (I) dans laquelle, m, n, R?1¿, R?2¿, Ra, ALK3, E et Y sont définis comme dans les revendications, lesdits composés étant des inhibiteurs efficaces et sélectifs de la chimiokine se fixant au récepteur CXCR3 et s'utilisant par conséquent dans le traitement et/ou la prévention d'états impliquant un trafic inappropriée des lymphocytes T, y compris des troubles inflammatoires, les troubles auto-immunes et les troubles de l'immuno-régulation, comme la polyarthrite rhumatoïde.
Meissner Johannes Wilhelm Georg
Owen David Alan
Watson Robert John
Celltech R. & D. Limited
Robic
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