Cyclic quaternary ammonium compounds

Details Cyclic quaternary ammonium compounds Cyclic quaternary ammonium compounds

C - Chemistry, Metallurgy

07

D

C07D 211/60 (2006.01) A61K 31/16 (2006.01) A61P 11/14 (2006.01) C07D 295/02 (2006.01) C07D 295/15 (2006.01)

Patent

CA 2393706

In one aspect, the present invention concerns the use of certain cyclic quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula (I) wherein n is an integer of from 0 to 4; R1 and E are independently selected from -CH2-R16 and a group represented by formula (II).

Dans un aspect, la présente invention concerne l'utilisation de certains composés cycliques d'ammonium quaternaire utilisés comme composant actif dans la fabrication d'un médicament destiné au traitement et/ou à la prévention de la toux chez les animaux à sang chaud, y compris les humains, tels que des composés correspondant à la formule (I) dans laquelle n est un nombre entier compris entre 0 et 4; R¿1? et E sont indépendamment sélectionnés entre -CH¿2?-R¿16? et un groupe représenté par la formule (II).

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