Cyclic renin inhibitors

Details Cyclic renin inhibitors Cyclic renin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 273/00 (2006.01) A61K 31/33 (2006.01) A61K 38/05 (2006.01) C07D 245/02 (2006.01) C07D 273/02 (2006.01) C07D 281/00 (2006.01) C07D 291/02 (2006.01) C07D 323/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 419/00 (2006.01) C07D 453/02 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2070972

94/MD53 95/MD54 96/MD55 97/MD56 17785IC TITLE OF THE INVENTION CYCLIC RENIN INHIBITORS CONTAINING 3(S)-AMINO-4- CYCLOHEXYL-2(R)-HYDROXY-BUTANOIC ACID OR 4-CYCLO- HEXYL-(2R, 3S)-DIHYDROXYBUTANOIC ACID OR RELATED ANALOGS ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image (I) 94/MD53 -i- 17785IC are disclosed. These compounds inhibit the angioten- sinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldo- steronism, congestive heart failure, and glaucoma.

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