Cyclic renin inhibitors

Details Cyclic renin inhibitors Cyclic renin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 273/01 (2006.01) A61K 31/33 (2006.01) A61K 38/05 (2006.01) C07D 267/00 (2006.01) C07D 273/00 (2006.01) C07D 323/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 413/00 (2006.01) C07D 453/02 (2006.01) C07D 487/04 (2006.01) C07F 9/6558 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2070978

85/MRD57 93/MRD58 91/MRD59 92/MRD60 18014IC TITLE OF THE INVENTION CYCLIC RENIN INHIBITORS WHICH CONTAIN 3(S)-AMINO-4- CYCLOHEXYL-2(R)-HYDROXY-BUTANOIC ACID OR 4-CYCLOHEXYL-(2R, 3S)- DIHYDROXYBUTANOIC ACID OR RELATED DIOL ANALOGS OR HYDROXYKETONE ANALOGS AND WHICH INCORPORATE L-SERINE OR RELATED ANALOGS AT THE P2 POSITION ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image (I) 85/MRD57 -i- 18014C are disclosed. These compounds inhibit the angioten- sinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldo- steronism, congestive heart failure, and glaucoma.

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