Cyclic renin inhibitors containing 2-substituted(3s,...

Details Cyclic renin inhibitors containing 2-substituted(3s,... Cyclic renin inhibitors containing 2-substituted(3s,...

C - Chemistry, Metallurgy

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C07K 5/06 (2006.01) C07D 245/02 (2006.01) C07D 267/00 (2006.01) C07D 273/00 (2006.01) C07D 281/00 (2006.01) C07D 285/00 (2006.01) C07D 321/00 (2006.01) C07D 327/02 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 453/02 (2006.01) C07D 487/04 (2006.01) C07F 9/547 (2006.01) C07F 9/655 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2031745

3/MRD2 12/MRD11 13/MRD12 14/MRD13 17784IB TITLE OF THE INVENTION CYCLIC RENIN INHIBITORS CONTAINING 2-SUBSTITUTED (3S,4S)-4-AMINO-5-CYCLOHEXYL-3-HYDROXY PENTANOIC ACID, 2-SUBSTITUTED (3S,4S)-5-CYCLOHEXYL-3,4-DI HYDROXYPENTANOIC ACID OR 2-SUBSTITUTED (4S,5S)-5- AMINO-6-CYCLOHEXYL-4-HYDROXYHEXANOIC ACID OR ITS ANALOGS ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image (I) 3/MRD2 12/MRD11 13/MRD12 14/MRD13 -i- l7784IB are disclosed. These compounds inhibit the angioten- sinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing renin-associated hypertension, hyperaldo- steronism, congestive heart failure, and glaucoma.

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