Cyclic somatostatin analogs

Details Cyclic somatostatin analogs Cyclic somatostatin analogs

C - Chemistry, Metallurgy

07

K

C07K 14/655 (2006.01) A61K 31/415 (2006.01) A61K 38/31 (2006.01) C07D 233/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2335184

The present invention is directed to cyclic derivatives containing an imidazole cis amide bond mimetic which bind selectively to somatostatin receptor subtypes and the use thereof in treating conditions which can be treated by eliciting an agonist or antagonist effect from the somatostatin subtype receptors. This invention is also directed to methods for making the compounds of the instant invention.

Cette invention se rapporte à des dérivés cycliques contenant un imitateur de liaison cis-amide d'imidazole, qui se fixent sélectivement à des sous-types de récepteurs de somatostatine, ainsi qu'à leur utilisation thérapeutique contre des états pathologiques que l'on peut traiter en déclenchant un effet agoniste ou antagoniste à partir des récepteurs de somatostatine de ces sous-types. Cette invention se rapporte également à des procédés servant à fabriquer ces composés.

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