Cyclic sulfone derivatives

Details Cyclic sulfone derivatives Cyclic sulfone derivatives

C - Chemistry, Metallurgy

07

C

C07C 317/50 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 317/44 (2006.01) C07C 323/61 (2006.01) C07C 323/65 (2006.01) C07D 207/30 (2006.01) C07D 209/48 (2006.01) C07D 213/64 (2006.01) C07D 213/65 (2006.01) C07D 307/34 (2006.01) C07D 333/04 (2006.01)

Patent

CA 2210056

Disclosed is a compound of the formula Image (wherein the broken line represents an optional double bond; n and q are 0, 1 or 2; p is 0 or l; X, Y and Z are each CR1R2; Ar is aryl or heteroaryl; and R1 and R2 are each hydrogen, alkyl or the like), useful in the treatment of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis or other diseases characterized by matrix metalloprotenase activity, as well as AIDS, sepsis, septic shock or other diseases involving the production of TNF.

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