Cyclic tertiary amine compound

Details Cyclic tertiary amine compound Cyclic tertiary amine compound

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/437 (2006.01) A61K 31/444 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/06 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2528929

A cyclic tertiary amine compound which is capable of inhibiting the production of inflammatory cytokine. It is either a compound having a structure represented by the following general formula (I): (I) (wherein A represents an optionally substituted trivalent group derived from pyrimidine, pyrrole, or the like; R1 represents optionally substituted aryl or heteroaryl; R2 represents optionally substituted heteroaryl; and R3 represents cyclic tertiary amino) or a pharmacologically acceptable salt of the compound.

L'invention concerne un composé d'amine tertiaire cyclique permettant d'inhiber la production de cytokine inflammatoire. Il consiste soit en un composé possédant une structure représentée par la formule générale (I), dans laquelle A représente un groupe trivalent éventuellement substitué dérivé de pyrimidine, pyrrole ou analogue; R?1¿ représente un aryle ou un hétéroaryle éventuellement substitué; R?2¿ représente un hétéroaryle éventuellement substitué; et R?3¿ représente un amino tertiaire cyclique; soit en un sel acceptable sur la plan pharmacologique de ce composé.

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