C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/34 (2006.01) A61K 31/4164 (2006.01) A61K 31/422 (2006.01) A61P 3/06 (2006.01) C07D 243/04 (2006.01) C07D 263/24 (2006.01) C07D 265/10 (2006.01) C07D 267/06 (2006.01)
Patent
CA 2678577
This invention relates to novel compounds of the Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 .beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
L'invention concerne des nouveaux composés de la formule (I), leurs sels pharmaceutiquement acceptables, et leurs compositions pharmaceutiques, qui sont utiles pour le traitement thérapeutique de maladies associées avec la modulation ou l'inhibition de 11b-HSD1 chez les mammifères. L'invention concerne en outre des compositions pharmaceutiques des nouveaux composés et des procédés pour leur utilisation dans la réduction ou le contrôle de la production de cortisol dans une cellule, ou l'inhibition de la conversion de la cortisone en cortisol dans une cellule.
Claremon David A.
Mcgeehan Gerard
Singh Suresh B.
Tice Colin M.
Ye Yuanjie
Gowling Lafleur Henderson Llp
Vitae Pharmaceuticals Inc.
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