C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/10 (2006.01) A61K 31/513 (2006.01) A61K 31/535 (2006.01) A61P 3/00 (2006.01) A61P 9/10 (2006.01) C07D 239/42 (2006.01) C07D 265/10 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2708303
This invention relates to novel compounds of the Formula (I), (Ia) and (Ib), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, j which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 .beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell Or the inhibition of the conversion of cortisone to Cortisol in a cell.
La présente invention concerne de nouveaux composés des formules (I), (Ia) et (Ib), des sels pharmaceutiquement acceptables de ceux-ci et des compositions pharmaceutiques de ceux-ci, qui sont utiles pour le traitement thérapeutique de maladies associées à la modulation ou à l'inhibition de la 11 ß-HSD1 chez des mammifères. L'invention concerne en outre des compositions pharmaceutiques des nouveaux composés et leurs procédés d'utilisation dans la réduction ou la régulation de la production de cortisol dans une cellule ou l'inhibition de la conversion de cortisone en cortisol dans une cellule.
Cacatian Salvacion
Claremon David A.
He Wei
Singh Suresh B.
Tice Colin M.
Gowling Lafleur Henderson Llp
Vitae Pharmaceuticals Inc.
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