Cyclin complex rearrangement and uses related thereto

Details Cyclin complex rearrangement and uses related thereto Cyclin complex rearrangement and uses related thereto

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2146965

A method and diagnostic kit for diagnosing transformation of a cell, involving detection of the subunit components of cyc- lin complexes, is disclosed. In particular, the method pertains to the interaction of cyclins, PCNA, CDKs, and low molecular weight polypeptides such as p21, p19 and p16. The invention further pertains to inhibitors of cell proliferation.

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