A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/54 (2006.01) A61K 31/47 (2006.01) C07D 219/06 (2006.01) C07D 219/08 (2006.01) C07D 285/24 (2006.01)
Patent
CA 2288154
Certain derivatives of acridones and benzothiadiazines have been found to have anti-cancer properties by virtue of their specific inhibition of the cyclin D dependant kinase CDK4. These molecules inhibit CDK4 activity more than they inhibit the activity of other such kinases (e.g. CDC2 and CDK2). This specificity results in an improved therapeutic index when used as drugs to treat susceptible cancers.
L'invention concerne certains dérivés d'acridones et de benzothiadiazines qui présentent des propriétés anticancéreuses en raison de leur capacité d'inhibition spécifique de la kinase dépendante de cycline D, CDK4. Les molécules en question inhibent l'activité de CDK4 davantage que l'activité d'autres kinases similaires (p. ex. CDC2 et CDK2). Cette spécificité permet d'obtenir un indice thérapeutique accru lorsque ces molécules sont utilisées comme médicaments pour traiter des cancers.
Dent Barry Roy
Kelley Michael J.
Nakagawa Kazuhiko
Industrial Research Limited
Smart & Biggar
United States Of America Represented By The Secretary Of The Department Of Health And Hum
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