Cyclin-dependent protein kinase

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 1/00 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2280206

An isolated nucleic acid molecule is disclosed which encodes a novel human cyclin-dependent kinase (CDK) which comprises a novel cyclin binding domain signature sequence and lacks several heretofore conserved amino acid residues involved in regulation of the cdk/cyclin complex. Associated proteins and biologically active mutant forms are also disclosed.

L'invention concerne une molécule d'acide nucléique isolée qui code une nouvelle kinase cyclino-dépendante (CDK = cyclin-dependent kinase) humaine qui comprend une nouvelle séquence de signature du domaine de liaison de la cycline et ne présente pas plusieurs résidus d'acide aminé, qui étaient conservés jusqu'à maintenant, impliqués dans la régulation du complexe cdk/cycline. L'invention concerne des protéines et des formes mutantes biologiquement actives associées.

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