Cyclised alpha-conotoxin peptides

Details Cyclised alpha-conotoxin peptides Cyclised alpha-conotoxin peptides

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/12 (2006.01) A61K 38/17 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2566832

This invention relates to synthetically cyclised .alpha.-conotoxin peptide having an amide cyclised backbone such that the peptide has no free N- or C- terminus, said peptide having the ability to inhibit a nicotinic acetylcholine receptor and comprising four cysteine residues bonded in pairs to form two disulfide bonds, wherein the N-terminus of the corresponding linear/non-cyclised conotoxin peptide is linked to the C- terminus by a peptide linker of such that between six and eight amino acid residues span the distance between cysteine residues I and IV.

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