C - Chemistry – Metallurgy – 07 – G
Patent
C - Chemistry, Metallurgy
07
G
C07G 3/00 (2006.01) A61K 31/70 (2006.01) A61K 35/407 (2006.01) A61K 35/50 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2264938
The application relates to the purification and characterisation of a family of A-type inositolphosphoglycans (IPGs) from human liver and placenta. These substances are shown to have the biological activity associated with A-type IPG fractions, namely regulating lipogenic activity and inhibiting cAMP dependent protein kinase. The characterisation of the compounds demonstrates that they contain metal ions, in particular Zn2+, and optionally phosphate. The compounds and their antagonists have uses as pharmaceuticals, e.g. for the treatment of diabetes, and in screening for synthetic analogues.
Purification et caractérisation d'une famille d'inositolphosphoglycannes (IPG) de type A provenant de foie et de placenta humains. Ces substances se sont révélé avoir une activité biologique associée à des fractions d'IPG de type A, à savoir la régulation de l'activité lipogène et l'inhibition de la protéine kinase dépendante de AMPc. La caractérisation des composés démontre qu'ils contiennent des ions métalliques, en particulier Zn?2+¿, et éventuellement du phosphate. Lesdits composés et leurs antagonistes peuvent être utilisés en tant que produits pharmaceutiques, par ex. pour le traitement du diabète, et pour cribler des analogues synthétiques.
Caro Hugo
Rademacher Thomas William
Bereskin & Parr
Rademacher Group Limited
Rodaris Pharmaceuticals Limited
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