Cyclitolamines

Details Cyclitolamines Cyclitolamines

C - Chemistry, Metallurgy

07

D

260/323, 260/605

C07D 295/04 (2006.01) C07D 207/08 (2006.01) C07D 211/22 (2006.01) C07D 213/79 (2006.01) C07D 213/80 (2006.01) C07D 295/096 (2006.01)

Patent

CA 1066290

Abstract The compounds of the invention have the formula Image or Image I Ia wherein Y is a radical of the formula Image or of the formula Image wherein (CH2)n is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R5 and R6 are the same or different and are hydrogen, alkyl, arylalkyl, or R5 and R6 together with the nitrogen to which they are attached are pyrrolidino, pipera- dino or N'-alkyl piperazino R1, R2, R3 or R4 are the same or different and are hydrogen; alkyl, trifluoromethyl; alkanoyl: haloalkanoyl: alkoxycarbonyl of the formula -?OR wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula Image wherein R5 and R6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl phenyl monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl; R7 and R8 are the same or different and are hydrogen or alkyl, or R7 and R8 taken together with the carbon atoms bearing substituents OR2 and OR4 form a cycloalkyl ring and R9 is alkyl of 1 to 4 carbons, phenyl, hydrogen, alkyl of 1 to 4 carbon atoms sub- stituted by phenyl or phenoxy or by a substituted phenyl or phenoxy radical wherein the substituent is halogen, amino, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbons or di- alkyl amino wherein each alkyl radical has 1 to 4 carbon atoms. These compounds have been found useful in the treatment of hypertension in mammalian species, e.g., rats, as surface active agents, as in vitro antibacterial compounds and as water softeners.

226312

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