Cyclization of peptides

Details Cyclization of peptides Cyclization of peptides

C - Chemistry, Metallurgy

07

K

530/1.06

C07K 1/00 (2006.01) C07K 1/06 (2006.01) C07K 14/585 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1045117

CYCLIZATION OF PEPTIDES ABSTRACT OF THE DISCLOSURE The synthesis of a disulfide cyclic peptide by preparing a non-cyclic peptide containing at least two cysteine moieties in its amino acid chain one of which is protected by an n-alkylthio group, and subjecting such non-cyclic peptide to a procedure in which the non-cyclic peptide is held in solution substantially free of oxygen at a pH of from about 5 to 10 until rearrangement takes place to yield a cyclic disulfide peptide and to displace said n-alkylthio group from said amino acid chain. The disclo- sure also embraces said non-cyclic peptides as new compounds and the processes by which they are prepared.

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