Cyclization to form cephem ring and intermediates therefor

Details Cyclization to form cephem ring and intermediates therefor Cyclization to form cephem ring and intermediates therefor

C - Chemistry, Metallurgy

07

D

260/242, 260/300

C07D 205/08 (2006.01) C07D 205/095 (2006.01) C07D 403/12 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1144924

ABSTRACT OF THE DISCLOSURE An intermediate represented by the following formula for synthesizing 3-hydroxy-3-cepham compounds. Image wherein A and B are, independently, hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted aralkanoyl or substituted or unsubstituted aroyl; R is hydrogen-ithiol group or an acyl group; x is hydroxy or carboxy-protecting group; Y is a carbonic acyloxy, disubstituted amino or aliphatic or aromatic sulfonyloxy and the broken line between a and R shows that, when R and B are hydrogens, A is a carboxylic acyl group.

337973

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