Cycloaliphatic pharmaceutical compounds

Details Cycloaliphatic pharmaceutical compounds Cycloaliphatic pharmaceutical compounds

C - Chemistry, Metallurgy

07

C

260/581, 260/567

C07C 49/513 (2006.01) C07C 49/517 (2006.01) C07C 59/82 (2006.01)

Patent

CA 1262142

ABSTRACT OF THE DISCLOSURE Novel pharmaceutical compounds, useful in anti-androgenic compositions, have the formulae: Image (I) or Image (II) In these formulae: B and B' are both H or together form a single bond; M1 and M2 are H, Cl, Br or I Q is CO, CH-OR, or CR-OH; each X is independently H or A; Y and Y' are independently H, halo, or A; A is -CRR-(CR1R2)nR3 n is an integer of from one to eight; R is H or lower alkyl; each R1 and R2 is independently R, OR, COOH, or CHO, or CR1R2 together form the group CO; R3 is H, COOR, OR, CHR-OR or COR; c is an integer from zero to four; and d is three or four; and p is zero or one provided that at least one A group is present and each A group contains at least one of COOR, CHO, CO, OR and COR, and not more than one of COOH, CO or COR, and wherein up to two ethylenic bonds may be present in the ring shown above. Pharmaceutically-acceptable salts of these compounds also are provided.

559370

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