Cycloalka¬b|pyridine-3-carbonylguanidine derivatives,...

Details Cycloalka¬b|pyridine-3-carbonylguanidine derivatives,... Cycloalka¬b|pyridine-3-carbonylguanidine derivatives,...

C - Chemistry, Metallurgy

07

D

C07D 215/54 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) C07D 215/60 (2006.01) C07D 221/04 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 491/04 (2006.01) C07D 491/052 (2006.01) C07D 491/056 (2006.01) C07D 491/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2283404

Drugs which contain cycloalka[b]pyridine-3-carbonylguanidine derivatives represented by general formula (1) and salts thereof and have inhibitory effects on sodium/proton (Na+/H+) exchange transport, wherein R1 represents hydrogen, halogeno, lower alkyl, lower alkoxy, aminated lower alkyl, lower alkoxyalkyl, aryl, a heterocycle, aralkyl, phenoxy-substituted lower alkyl or aralkyloxy-substituted lower alkyl; R2 represents hydrogen, halogeno, lower alkoxy or nitro; A represents a single bond or vinylene; B represents vinylene, etc.; D represents a single bond, methylene or ethylene; and E represents vinylene, etc.

L'invention concerne des médicaments contenant des dérivés de cycloalca[b]pyridine-3-carbonylguanidine représentés par la formule générale (1) ainsi que leurs sels, lesquels présentent des effets inhibiteurs sur le transport par échange sodium/proton (Na?+¿/H?+¿), formule dans laquelle R?1¿ représente hydrogène, halogéno, alkyle inférieur, alcoxy inférieur, alkyle inférieur aminé, alcoxyalkyle inférieur, aryle, un hétérocycle, aralkyle, alkyle inférieur à substitution phénoxy ou alkyle inférieur à substitution aralkyloxy; R?2¿ représente hydrogène, halogéno, alcoxy ou nitro inférieur; A représente une liaison simple ou vinylène; B représente vinylène, etc.; D représente une liaison simple, méthylène ou éthylène; et E représente vinylène, etc.

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