Cycloalkane derivatives

Details Cycloalkane derivatives Cycloalkane derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/227 (2006.01) A61K 31/12 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07C 45/00 (2006.01) C07C 45/30 (2006.01) C07C 45/51 (2006.01) C07C 45/62 (2006.01) C07C 45/66 (2006.01) C07C 45/68 (2006.01) C07C 45/71 (2006.01) C07C 45/74 (2006.01) C07C 49/747 (2006.01) C07C 49/753 (2006.01) C07C 49/84 (2006.01) C07D 217/24 (2006.01) C07D 265/36 (2006.01) C07D 279/16 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2094465

A B S T R A C T CYCLOALKANE DERIVATIVES The invention concerns cycloalkane derivatives of the formula I Image I wherein Ar1 is phenyl, naphthyl or a 10-membered bicyclic heterocyclic moiety which may optionally bear up to four substituents; A1 is a direct link to X1 or is (1-3C)alkylene; X1 is oxy, thio, sulphinyl or sulphonyl; Ar2 is phenylene, pyridylene, pyrimidinylene, thiophenediyl, furandiyl, thiazolediyl or oxazolediyl which may optionally bear one or two substituents; p is 1 to 4; q is 0 to 2; R1 is hydrogen, (1-4C)alkyl, (2-4C)alkenyl or (3-4C)alkynyl; R2 is hydrogen, hydroxy, (1-4C)alkyl, (1-4C)alkoxy, (2-4C)alkenyloxy or (3-4C)alkynyloxy; or the OR1 and R2 groups together form a (1-4C)alkylenedioxy, oxo, thioxo, imino, hydroxyimino or (1-4C)alkoxyimino group; r is 0 to 3; and R3 is halogeno, trifluoromethyl or (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.

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