Cycloalkano[1,2-b]indole-sulphonamides

Details Cycloalkano[1,2-b]indole-sulphonamides Cycloalkano[1,2-b]indole-sulphonamides

C - Chemistry, Metallurgy

07

D

167/240, 260/317

C07D 209/82 (2006.01) A61K 31/40 (2006.01) C07D 209/80 (2006.01) C07D 209/86 (2006.01) C07D 209/88 (2006.01) C07D 209/94 (2006.01) C07D 491/10 (2006.01)

Patent

CA 1309414

ABSTRACT OF THE DISCLOSURE Cycloalkano[1,2-b]indole-sulphonamides of the formula Image in which R1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, represents a group of the formula -S(O)mR3, in which R denotes alkyl or aryl, and m denotes one of the numbers 0, 1 or 2, represents a group of the formula Image in which R4 and R5 are identical or different and represent hydrogen, alkyl, aryl, aralkyl or acetyl, repre- sents a group of the formula -OR6, in which R6 denotes hydrogen, alkyl, aryl, aralkyl, alkyl- SO2-, aryl-SO2-, aralkyl-SO2- or trifluoro- methyl, or represents alkyl, alkenyl or cycloalkyl, each of which is optionally substituted by carboxyl, alkoxycarbonyl, halogen, hydroxyl, alkoxy, alkyl- thio or cyano, R2 represents aryl which is optionally substitu- ted up to 5 times by halogen, cyano, trifluoro- methyl, trifluoromethoxy, trifluoromethylthio, alkyl, carboxyalkyl, alkoxycarbonylslkyl, alkoxy, Le A 24 325 alkylthio, hydroxyl, carboxyl, alkoxycarbonyl, phenyl, phenoxy, benzyloxy, benzylthio or a group of the formula Image in which R4 and R5 have the abovementioned meaning, x represents the number 1, 2 or 3, and y represents the number 0 or 1, where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A2.

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