Cycloalkanopyridine derivative

Details Cycloalkanopyridine derivative Cycloalkanopyridine derivative

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/403 (2006.01) A61K 31/438 (2006.01) A61K 31/4545 (2006.01) A61K 31/46 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/55 (2006.01) A61P 3/04 (2006.01) A61P 9/00 (2006.01) A61P 13/00 (2006.01) A61P 25/02 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/36 (2006.01) A61P 43/00 (2006.01) C07D 451/00 (2006.01) C07D 471/04 (2006.01) C07D 487/10 (2006.01) C07D 491/10 (2006.01) C07D 491/20 (2006.01) C07D 491/22 (2006.

Patent

CA 2558274

A cycloalkanopyridine derivative represented by the general formula [I] wherein A1 to A4 each independently represents -C(R5)- or -N-, provided that at least one of A1 to A4 represents -N-; A5 to A8 each independently represents -C(R6)- or -N-; X represents -CH2-, -CH(OH)-, -N(Ra)-, -O-, -S-, or -SO2-; Y represents -CH2- or -N(Ra)-; Z represents -(CR7)- or -N-; n is 0 or 1; and R1 to R4 each represents hydrogen or a group, etc. This compound functions as a nociceptin receptor antagonist. It is useful as, e.g., a drug for overcoming resistance to narcotic analgesics for diseases in which a nociceptin receptor participates.

Dérivé cycloalkanopyridine représenté par la formule générale [I] où A1 à A4 représentent chacun indépendamment - C(R6)- ou -N-; X représente -CH¿2?-, -CH(OH)-, -N(Ra)-, -O-, -S-, ou -SO¿2?-; Y représente -CH¿2?- or -N(Ra)-; Z représente -(CR7)- ou -N-; n est 0 ou 1; et R1 à R4 représentent chacun de l~hydrogène ou un groupe, etc. Ce composé fonctionne comme un antagoniste de récepteur de nociceptine. Il peut être utilisé par exemple comme médicament contre la résistance aux narcotiques pour les maladies dans lesquelles participe un récepteur de nocipetpine.

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