Cycloalkyl amine bis-aryl squalene synthase inhibitors

Details Cycloalkyl amine bis-aryl squalene synthase inhibitors Cycloalkyl amine bis-aryl squalene synthase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 263/57 (2006.01) A61K 31/135 (2006.01) A61K 31/33 (2006.01) C07C 217/52 (2006.01) C07C 225/20 (2006.01) C07D 209/14 (2006.01) C07D 215/14 (2006.01) C07D 277/66 (2006.01) C07D 307/80 (2006.01) C07D 307/81 (2006.01) C07D 311/58 (2006.01) C07D 317/58 (2006.01) C07D 333/58 (2006.01)

Patent

CA 2152912

This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted thereon a primary amine and which is further linked or bridged to two mono- and/or bicyclic rings and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

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