Cycloalkyl inhibitors of potassium channel function

Details Cycloalkyl inhibitors of potassium channel function Cycloalkyl inhibitors of potassium channel function

C - Chemistry, Metallurgy

07

C

C07C 279/28 (2006.01) A61K 31/155 (2006.01) A61K 31/165 (2006.01) A61K 31/18 (2006.01) A61K 31/277 (2006.01) A61K 31/381 (2006.01) A61K 31/395 (2006.01) A61K 31/4164 (2006.01) A61K 31/42 (2006.01) A61K 31/4245 (2006.01) A61K 31/47 (2006.01) A61K 31/517 (2006.01) A61K 31/5375 (2006.01) C07C 233/02 (2006.01) C07C 233/57 (2006.01) C07C 279/16 (2006.01) C07C 307/08 (2006.01) C07C 311/52 (2006.01) C07D 213/75 (2006.01) C07D 217/22 (2006.01) C07D 233/40 (2006.01) C07D 233/74 (2006.01) C07D 271/06 (2006.01) C07D 2

Patent

CA 2474451

Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.

L'invention porte sur de nouveaux composés cycloalkyle utiles comme inhibiteurs de la fonction du canal de potassium (notamment les inhibiteurs de la sous-famille K¿v?1 des canaux K?+¿ sensibles au voltage, et en particulier les inhibiteurs Kv1.5 qui ont été liés au courant I¿Kur? K?+¿ redresseur retardé à activation ultra-rapide). L'invention porte également sur des procédés d'utilisation de ces composés dans la prévention et le traitement de l'arythmie et des états associés à I¿Kur?, et sur des compositions pharmaceutiques contenant ces composés.

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